CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Hua enhancer1 |
Enzyme Information
| 2.1.1.n8 |
Small RNA 2'-O-methyltransferase.
based on mapping to UniProt Q9C5Q8
S-adenosyl-L-methionine + small RNA = S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide.
-!- Adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs). -!- This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation. -!- Can methylates 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs).
|
UniProtKB Entries (1)
| Q9C5Q8 |
HEN1_ARATH
Arabidopsis thaliana
Small RNA 2'-O-methyltransferase
|
PDB Structure
| PDB | 3HTX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into mechanisms of the small RNA methyltransferase HEN1.
Nature
|
