CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.129 | Thiol Ester Dehydrase; Chain A |
|
3.10.129.110 | Polyketide synthase dehydratase |
Domain Context
CATH Clusters
| Superfamily | Polyketide synthase dehydratase |
| Functional Family | Sterigmatocystin biosynthesis polyketide synthase |
Enzyme Information
| 2.3.1.221 |
Noranthrone synthase.
based on mapping to UniProt Q12053
7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO(2) + 2 H(2)O.
-!- A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. -!- The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase.
|
UniProtKB Entries (1)
| Q12053 |
AFLC_ASPPU
Aspergillus parasiticus SU-1
Norsolorinic acid synthase
|
PDB Structure
| PDB | 3HRQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Nature
|
