CATH Domain 3hphA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P35956
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P35956
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P35956 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.6.1.23	dUTP diphosphatase. based on mapping to UniProt P35956 dUTP + H(2)O = dUMP + diphosphate.
3.1.13.2	Exoribonuclease H. based on mapping to UniProt P35956 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. -!- This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13.
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P35956 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P35956 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
3.1.-.-	Acting on ester bonds. based on mapping to UniProt P35956

UniProtKB Entries (2)

O75475	PSIP1_HUMAN Homo sapiens PC4 and SFRS1-interacting protein
P35956	POL_VILVK Visna/maedi virus EV1 KV1772 Gag-Pol polyprotein

PDB Structure

PDB	3HPH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for functional tetramerization of lentiviral integrase Hare, S., Di Nunzio, F., Labeja, A., Wang, J., Engelman, A., Cherepanov, P. Plos Pathog.