CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O00141
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O00141
SGK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Sgk1

PDB Structure

PDB 3HDN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Hammond, M., Washburn, D.G., Hoang, H.T., Manns, S., Frazee, J.S., Nakamura, H., Patterson, J.R., Trizna, W., Wu, C., Azzarano, L.M., Nagilla, R., Nord, M., Trejo, R., Head, M.S., Zhao, B., Smallwood, A.M., Hightower, K., Laping, N.J., Schnackenberg, C.G., Thompson, S.K.
Bioorg.Med.Chem.Lett.
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