CATH Domain 3ha6A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Aurora kinase A

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14965

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965

AURKA_HUMAN

Homo sapiens

Aurora kinase A

PDB Structure

PDB	3HA6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis and selection of DNA-encoded small-molecule libraries. Clark, M.A., Acharya, R.A., Arico-Muendel, C.C., Belyanskaya, S.L., Benjamin, D.R., Carlson, N.R., Centrella, P.A., Chiu, C.H., Creaser, S.P., Cuozzo, J.W., Davie, C.P., Ding, Y., Franklin, G.J., Franzen, K.D., Gefter, M.L., Hale, S.P., Hansen, N.J., Israel, D.I., Jiang, J., Kavarana, M.J., Kelley, M.S., Kollmann, C.S., Li, F., Lind, K., Mataruse, S., Medeiros, P.F., Messer, J.A., Myers, P., O'Keefe, H., Oliff, M.C., Rise, C.E., Satz, A.L., Skinner, S.R., Svendsen, J.L., Tang, L., van Vloten, K., Wagner, R.W., Yao, G., Zhao, B., Morgan, B.A. Nat.Chem.Biol.