CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | (S)-hydroxynitrile lyase |
Enzyme Information
| 3.1.1.78 |
Polyneuridine-aldehyde esterase.
based on mapping to UniProt Q9SE93
Polyneuridine aldehyde + H(2)O = 16-epivellosimine + CO(2) + methanol.
-!- Following hydrolysis of this indole alkaloid ester, the carboxylic acid decarboxylates spontaneously giving the sarpagan skeleton. -!- Also acts on akuammidine aldehyde (the 16-epimer of polyneuridine aldehyde).
|
UniProtKB Entries (1)
| Q9SE93 |
PNAE_RAUSE
Rauvolfia serpentina
Polyneuridine-aldehyde esterase
|
PDB Structure
| PDB | 3GZJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids
Angew.Chem.Int.Ed.Engl.
|