CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Mitomycin biosynthesis 6-O-methyltransferase |
Enzyme Information
| 2.1.1.316 |
Mitomycin 6-O-methyltransferase.
based on mapping to UniProt Q9X5T6
(1) S-adenosyl-L-methionine + 6-demethylmitomycin A = S-adenosyl-L- homocysteine + mitomycin A. (2) S-adenosyl-L-methionine + 6-demethylmitomycin B = S-adenosyl-L- homocysteine + mitomycin B.
-!- The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B.
|
UniProtKB Entries (1)
| Q9X5T6 |
MMCR_STRLA
Streptomyces lavendulae
Mitomycin biosynthesis 6-O-methyltransferase
|
PDB Structure
| PDB | 3GWZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins
|
