CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.160 | Porin | |
2.40.160.20 |
Domain Context
CATH Clusters
Superfamily | 2.40.160.20 |
Functional Family | Lipid A palmitoyltransferase PagP |
Enzyme Information
2.3.1.251 |
Lipid IV(A) palmitoyltransferase.
based on mapping to UniProt P37001
(1) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A. (2) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid II(A) = 2-acyl-sn-glycero-3-phosphocholine + lipid II(B). (3) 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IV(A) = 2-acyl-sn-glycero-3-phosphocholine + lipid IV(B).
-!- Isolated from the bacteria Escherichia coli and Salmonella typhimurium. -!- The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position. -!- There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds. -!- The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IV(A).
|
UniProtKB Entries (1)
P37001 |
PAGP_ECOLI
Escherichia coli K-12
Lipid A palmitoyltransferase PagP
|
PDB Structure
PDB | 3GP6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.
Structure
|