CATH Classification
Domain Context
CATH Clusters
| Superfamily | 2.40.50.100 |
| Functional Family | Maltose/maltodextrin import ATP-binding protein MalK |
Enzyme Information
| 5.6.1.6 |
Channel-conductance-controlling ATPase.
based on mapping to UniProt P13569
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.
-!- ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. -!- The enzyme is found in animals, and in humans its absence brings about cystic fibrosis. -!- Unlike most of the ABC transporters, chloride pumping is not directly coupled to ATP hydrolysis. -!- Instead, the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. -!- The enzyme is also involved in the functioning of other transmembrane channels. -!- Formerly EC 3.6.3.49.
|
| 7.5.2.1 |
ABC-type maltose transporter.
based on mapping to UniProt P68187
ATP + H(2)O + maltose-[maltose-binding protein](Side 1) = ADP + phosphate + maltose(Side 2) + [maltose-binding protein](Side 1).
-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of maltose and maltose oligosaccharides. -!- Formerly EC 3.6.3.19.
|
UniProtKB Entries (2)
| P68187 |
MALK_ECOLI
Escherichia coli K-12
Maltose/maltodextrin import ATP-binding protein MalK
|
| P13569 |
CFTR_HUMAN
Homo sapiens
Cystic fibrosis transmembrane conductance regulator
|
PDB Structure
| PDB | 3GD7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP)
To be Published
|
