CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
Superfamily | Vaccinia Virus protein VP39 |
Functional Family |
Enzyme Information
2.1.1.182 |
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase.
based on mapping to UniProt Q5SM60
4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
-!- KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. -!- Strains lacking the methylase are resistant to kasugamycin. -!- Formerly EC 2.1.1.48.
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UniProtKB Entries (1)
Q5SM60 |
RSMA_THET8
Thermus thermophilus HB8
Ribosomal RNA small subunit methyltransferase A
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PDB Structure
PDB | 3FUT |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.
J.Mol.Biol.
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