CATH Domain 3f6xA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P00523

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523

SRC_CHICK

Gallus gallus

Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB	3F6X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tuning a three-component reaction for trapping kinase substrate complexes. Statsuk, A.V., Maly, D.J., Seeliger, M.A., Fabian, M.A., Biggs, W.H., Lockhart, D.J., Zarrinkar, P.P., Kuriyan, J., Shokat, K.M. J.Am.Chem.Soc.