CATH Domain 3et7A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	protein-tyrosine kinase 2-beta isoform X2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q14289

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14289

FAK2_HUMAN

Homo sapiens

Protein-tyrosine kinase 2-beta

PDB Structure

PDB	3ET7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. Walker, D.P., Bi, F.C., Kalgutkar, A.S., Bauman, J.N., Zhao, S.X., Soglia, J.R., Aspnes, G.E., Kung, D.W., Klug-McLeod, J., Zawistoski, M.P., McGlynn, M.A., Oliver, R., Dunn, M., Li, J.C., Richter, D.T., Cooper, B.A., Kath, J.C., Hulford, C.A., Autry, C.L., Luzzio, M.J., Ung, E.J., Roberts, W.G., Bonnette, P.C., Buckbinder, L., Mistry, A., Griffor, M.C., Han, S., Guzman-Perez, A. Bioorg.Med.Chem.Lett.