CATH Domain 3eq7A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.120	Prolyl oligopeptidase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Prolyl oligopeptidase, N-terminal domain
Functional Family	Prolyl endopeptidase

Enzyme Information

3.4.21.26

Prolyl oligopeptidase.

based on mapping to UniProt P23687

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P23687

PPCE_PIG

Sus scrofa

Prolyl endopeptidase

PDB Structure

PDB	3EQ7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules Kanai, K., Aranyi, P., Bocskei, Z., Ferenczy, G., Harmat, V., Simon, K., Batori, S., Naray-Szabo, G., Hermecz, I. J.Med.Chem.