CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.190 | D-Maltodextrin-Binding Protein; domain 2 |
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3.40.190.10 | Periplasmic binding protein-like II |
Domain Context
CATH Clusters
Superfamily | Periplasmic binding protein-like II |
Functional Family | Porphobilinogen deaminase |
Enzyme Information
2.5.1.61 |
Hydroxymethylbilane synthase.
based on mapping to UniProt P08397
4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3).
-!- The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active center. -!- The terminal tetrapyrrole is then hydrolyzed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. -!- In the presence of a second enzyme, EC 4.2.1.75, which is often called cosynthase, the product is cyclized to form uroporphyrinogen III. -!- If EC 4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I. -!- Formerly EC 4.3.1.8.
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UniProtKB Entries (1)
P08397 |
HEM3_HUMAN
Homo sapiens
Porphobilinogen deaminase
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PDB Structure
PDB | 3EQ1 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of human porphobilinogen deaminase at 2.8 A: the molecular basis of acute intermittent porphyria
Biochem.J.
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