CATH Domain 3epiA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1490	Dna Ligase; domain 1
	3.30.1490.100	DNA polymerase, Y-family, little finger domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, Y-family, little finger domain
Functional Family	Polymerase (DNA directed) iota

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q9UNA4

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9UNA4

POLI_HUMAN

Homo sapiens

DNA polymerase iota

PDB Structure

PDB	3EPI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Lesion bypass of N2-ethylguanine by human DNA polymerase iota. Pence, M.G., Blans, P., Zink, C.N., Hollis, T., Fishbein, J.C., Perrino, F.W. J.Biol.Chem.