CATH Domain 3elmA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt P45452

UniProtKB Entries (1)

MMP13_HUMAN

Homo sapiens

Collagenase 3

PDB Structure

PDB	3ELM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 Monovich, L.G., Tommasi, R.A., Fujimoto, R.A., Blancuzzi, V., Clark, K., Cornell, W.D., Doti, R., Doughty, J., Fang, J., Farley, D., Fitt, J., Ganu, V., Goldberg, R., Goldstein, R., Lavoie, S., Kulathila, R., Macchia, W., Parker, D.T., Melton, R., O'Byrne, E., Pastor, G., Pellas, T., Quadros, E., Reel, N., Roland, D.M., Sakane, Y., Singh, H., Skiles, J., Somers, J., Toscano, K., Wigg, A., Zhou, S., Zhu, L., Shieh, W.C., Xue, S., McQuire, L.W. J.Med.Chem.