CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase |
Enzyme Information
| 4.2.3.47 |
Beta-farnesene synthase.
based on mapping to UniProt Q9K498
(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate.
|
| 1.14.13.106 |
Epi-isozizaene 5-monooxygenase.
based on mapping to UniProt Q9K498
(+)-epi-isozizaene + 2 NADPH + 2 O(2) = albaflavenone + 2 NADP(+) + 3 H(2)O.
-!- This enzyme, from the soil-dwelling bacterium Streptomyces coelicolor A3(2), catalyzes two sequential allylic oxidation reactions. -!- The substrate epi-isozizaene, which is formed by the action of EC 4.2.3.37 is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone.
|
UniProtKB Entries (1)
| Q9K498 |
EIZFM_STRCO
Streptomyces coelicolor A3(2)
Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase
|
PDB Structure
| PDB | 3EL3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site
J.Biol.Chem.
|