CATH Domain 3e80C03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.2750

Domain Context

CATH Clusters

Superfamily	2.60.40.2750
Functional Family	Heparin and heparin-sulfate lyase

Enzyme Information

4.2.2.8	Heparin-sulfate lyase. based on mapping to UniProt C6XZB6 Elimination of sulfate, appears to act on linkages between N-acetyl-D- glucosamine and uronate. Product is an unsaturated sugar. -!- Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages.
4.2.2.7	Heparin lyase. based on mapping to UniProt C6XZB6 Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non- reducing ends.

UniProtKB Entries (1)

HEPB_PEDHD

Pedobacter heparinus DSM 2366

Heparin and heparin-sulfate lyase

PDB Structure

PDB	3E80
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate. Shaya, D., Zhao, W., Garron, M.L., Xiao, Z., Cui, Q., Zhang, Z., Sulea, T., Linhardt, R.J., Cygler, M. J.Biol.Chem.