CATH Domain 3dxjE00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.940	Eukaryotic RPB6 RNA polymerase subunit
	3.90.940.10	RNA polymerase subunit, RPB6/omega

Domain Context

CATH Clusters

Superfamily	3.90.940.10
Functional Family

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt Q8RQE7

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q8RQE7

RPOZ_THET8

Thermus thermophilus HB8

DNA-directed RNA polymerase subunit omega

PDB Structure

PDB	3DXJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The RNA polymerase "switch region" is a target for inhibitors. Mukhopadhyay, J., Das, K., Ismail, S., Koppstein, D., Jang, M., Hudson, B., Sarafianos, S., Tuske, S., Patel, J., Jansen, R., Irschik, H., Arnold, E., Ebright, R.H. Cell(Cambridge,Mass.)