CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
Enzyme Information
1.1.1.146 |
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q6QLL4
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
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UniProtKB Entries (1)
Q6QLL4 |
DHI1_CAVPO
Cavia porcellus
Corticosteroid 11-beta-dehydrogenase isozyme 1
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PDB Structure
PDB | 3DWF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system
Protein Sci.
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