CATH Domain 3dduA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Prolyl endopeptidase

Enzyme Information

3.4.21.26

Prolyl oligopeptidase.

based on mapping to UniProt P48147

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

-!- Found in vertebrates, plants and Flavobacterium. -!- Generally cytosolic, commonly activated by thiol compounds. -!- Belongs to peptidase family S9A. -!- Formerly EC 3.4.22.18.

UniProtKB Entries (1)

P48147

PPCE_HUMAN

Homo sapiens

Prolyl endopeptidase

PDB Structure

PDB	3DDU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP) Haffner, C.D., Diaz, C.J., Miller, A.B., Reid, R.A., Madauss, K.P., Hassell, A., Hanlon, M.H., Porter, D.J., Becherer, J.D., Carter, L.H. Bioorg.Med.Chem.Lett.