CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.70 | Alpha-Beta Plaits |
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3.30.70.1390 | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 |
Domain Context
CATH Clusters
Superfamily | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 |
Functional Family | Leucine-rich repeat serine/threonine-protein kinase 2 |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q5S007
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
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UniProtKB Entries (1)
Q5S007 |
LRRK2_HUMAN
Homo sapiens
Leucine-rich repeat serine/threonine-protein kinase 2
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PDB Structure
PDB | 3D6T |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Proc.Natl.Acad.Sci.Usa
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