CATH Domain 3d4fA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P0AD64

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64

BLA1_KLEPN

Klebsiella pneumoniae

Beta-lactamase SHV-1

PDB Structure

PDB	3D4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE Pattanaik, P., Bethel, C.R., Hujer, A.M., Hujer, K.M., Distler, A.M., Taracila, M., Anderson, V.E., Fritsche, T.R., Jones, R.N., Pagadala, S.R., van den Akker, F., Buynak, J.D., Bonomo, R.A. J.Biol.Chem.