CATH Domain 3d3lB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.245	Lipoxygenase-1; domain 5
	1.20.245.10	Lipoxygenase-1; Domain 5

Domain Context

CATH Clusters

Superfamily	Lipoxygenase-1; Domain 5
Functional Family	Arachidonate 5-lipoxygenase a

Enzyme Information

3.3.2.-	Ether hydrolases. based on mapping to UniProt P18054
1.13.11.31	Arachidonate 12-lipoxygenase. based on mapping to UniProt P18054 Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate. -!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.

UniProtKB Entries (1)

LOX12_HUMAN

Homo sapiens

Arachidonate 12-lipoxygenase, 12S-type

PDB Structure

PDB	3D3L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the lipoxygenase domain of human Arachidonate 12-lipoxygenase, 12S-type. Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Svensson, L., Thorsell, A.G., Van Den Berg, S., Welin, M., Weigelt, J., Wikstrom, M., Nordlund, P. To be Published