CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P97477
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Mus musculus
Aurora kinase A

PDB Structure

PDB 3D14
External Links
Primary Citation
Discovery of a potent and selective aurora kinase inhibitor.
Oslob, J.D., Romanowski, M.J., Allen, D.A., Baskaran, S., Bui, M., Elling, R.A., Flanagan, W.M., Fung, A.D., Hanan, E.J., Harris, S., Heumann, S.A., Hoch, U., Jacobs, J.W., Lam, J., Lawrence, C.E., McDowell, R.S., Nannini, M.A., Shen, W., Silverman, J.A., Sopko, M.M., Tangonan, B.T., Teague, J., Yoburn, J.C., Yu, C.H., Zhong, M., Zimmerman, K.M., O'Brien, T., Lew, W.