CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.274 | Enzyme I; Chain A, domain 2 |
|
1.10.274.100 | RNA polymerase Rpb1, domain 3 |
Domain Context
CATH Clusters
| Superfamily | RNA polymerase Rpb1, domain 3 |
| Functional Family | DNA-directed RNA polymerase subunit |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P27999 |
RPB9_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB9
|
PDB Structure
| PDB | 3CQZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
Mol.Cell
|
