CATH Domain 3ckyB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	2-hydroxymethylglutarate dehydrogenase

Enzyme Information

1.1.1.291

2-hydroxymethylglutarate dehydrogenase.

based on mapping to UniProt Q0QLF5

(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.

-!- NADP(+) cannot replace NAD(+). -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.

UniProtKB Entries (1)

Q0QLF5

HMGD_EUBBA

Eubacterium barkeri

2-(hydroxymethyl)glutarate dehydrogenase

PDB Structure

PDB	3CKY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Kinetic Properties of a beta-Hydroxyacid Dehydrogenase Involved in Nicotinate Fermentation. Reitz, S., Alhapel, A., Essen, L.O., Pierik, A.J. J.Mol.Biol.