CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | spermine synthase |
Enzyme Information
| 2.5.1.22 |
Spermine synthase.
based on mapping to UniProt P52788
S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl- 5'-thioadenosine + spermine.
-!- The enzyme from mammalia is highly specific for spermidine, cf. EC 2.5.1.16 and EC 2.5.1.23.
|
UniProtKB Entries (1)
| P52788 |
SPSY_HUMAN
Homo sapiens
Spermine synthase
|
PDB Structure
| PDB | 3C6M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
J.Biol.Chem.
|
