CATH Domain 3c6mB01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.160	Double Stranded RNA Binding Domain
	3.30.160.110	Siroheme synthase; domain 2

Superfamily	Siroheme synthase; domain 2
Functional Family	spermine synthase

2.5.1.22

Spermine synthase.

based on mapping to UniProt P52788

S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl- 5'-thioadenosine + spermine.

-!- The enzyme from mammalia is highly specific for spermidine, cf. EC 2.5.1.16 and EC 2.5.1.23.

SPSY_HUMAN

Homo sapiens

Spermine synthase

PDB	3C6M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. Wu, H., Min, J., Zeng, H., McCloskey, D.E., Ikeguchi, Y., Loppnau, P., Michael, A.J., Pegg, A.E., Plotnikov, A.N. J.Biol.Chem.