CATH Domain 3c4oA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P0AD64

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (2)

P35804	BLIP_STRCL Streptomyces clavuligerus Beta-lactamase inhibitory protein
P0AD64	BLA1_KLEPN Klebsiella pneumoniae Beta-lactamase SHV-1

PDB Structure

PDB	3C4O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. Reynolds, K.A., Hanes, M.S., Thomson, J.M., Antczak, A.J., Berger, J.M., Bonomo, R.A., Kirsch, J.F., Handel, T.M. J.Mol.Biol.