CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
Enzyme Information
| 1.1.1.41 |
Isocitrate dehydrogenase (NAD(+)).
based on mapping to UniProt P28241
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.
-!- Unlike EC 1.1.1.42, oxalosuccinate cannot be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NADP(+) but much more slowly.
|
UniProtKB Entries (1)
| P28241 |
IDH2_YEAST
Saccharomyces cerevisiae S288C
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
|
PDB Structure
| PDB | 3BLX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase.
J.Biol.Chem.
|