CATH Domain 3belA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P00533

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533

EGFR_HUMAN

Homo sapiens

Epidermal growth factor receptor

PDB Structure

PDB	3BEL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases. Xu, G., Searle, L.L., Hughes, T.V., Beck, A.K., Connolly, P.J., Abad, M.C., Neeper, M.P., Struble, G.T., Springer, B.A., Emanuel, S.L., Gruninger, R.H., Pandey, N., Adams, M., Moreno-Mazza, S., Fuentes-Pesquera, A.R., Middleton, S.A., Greenberger, L.M. Bioorg.Med.Chem.Lett.