CATH Domain 3b8zA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	A disintegrin and metalloproteinase with thrombospondin motifs 1

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt Q9UNA0

UniProtKB Entries (1)

ATS5_HUMAN

Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 5

PDB Structure

PDB	3B8Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2). Shieh, H.S., Mathis, K.J., Williams, J.M., Hills, R.L., Wiese, J.F., Benson, T.E., Kiefer, J.R., Marino, M.H., Carroll, J.N., Leone, J.W., Malfait, A.M., Arner, E.C., Tortorella, M.D., Tomasselli, A. J.Biol.Chem.