CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.630 | Cytochrome p450 | |
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450 |
Functional Family | Prostaglandin I2 (prostacyclin) synthase |
Enzyme Information
5.3.99.4 |
Prostaglandin-I synthase.
based on mapping to UniProt Q16647
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
-!- Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).
|
UniProtKB Entries (1)
Q16647 |
PTGIS_HUMAN
Homo sapiens
Prostacyclin synthase
|
PDB Structure
PDB | 3B6H |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
J.Biol.Chem.
|