CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Prostaglandin I2 (prostacyclin) synthase

Enzyme Information

5.3.99.4
Prostaglandin-I synthase.
based on mapping to UniProt Q16647
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
-!- Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).

UniProtKB Entries (1)

Q16647
PTGIS_HUMAN
Homo sapiens
Prostacyclin synthase

PDB Structure

PDB 3B6H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
Li, Y.-C., Chiang, C.-W., Yeh, H.-C., Hsu, P.-Y., Whitby, F.G., Wang, L.-H., Chan, N.-L.
J.Biol.Chem.