CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Chalcone synthase 2 |
Enzyme Information
| 2.3.1.211 |
Bisdemethoxycurcumin synthase.
based on mapping to UniProt Q8LIL0
2 4-coumaroyl-CoA + malonyl-CoA + H(2)O = 3 CoA + bisdemethoxycurcumin + 2 CO(2).
-!- A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyzes the formation of the C(6)-C(7)-C(6) diarylheptanoid scaffold of bisdemethoxycurcumin. -!- Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes, the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment. -!- Formerly EC 2.3.1.n9.
|
UniProtKB Entries (1)
| Q8LIL0 |
CUS_ORYSJ
Oryza sativa Japonica Group
Bisdemethoxycurcumin synthase
|
PDB Structure
| PDB | 3ALE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Proc.Natl.Acad.Sci.USA
|