CATH Domain 3al6D01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.650	Cupin

Domain Context

CATH Clusters

Superfamily	Cupin
Functional Family	tRNA wybutosine-synthesizing protein 5

Enzyme Information

1.14.11.42

tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.

based on mapping to UniProt A2RUC4

7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).

-!- The enzyme is not active with wybutosine.

UniProtKB Entries (1)

A2RUC4

TYW5_HUMAN

Homo sapiens

TRNA wybutosine-synthesizing protein 5

PDB Structure

PDB	3AL6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. Kato, M., Araiso, Y., Noma, A., Nagao, A., Suzuki, T., Ishitani, R., Nureki, O. Nucleic Acids Res.