CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD |
Enzyme Information
| 4.1.2.43 |
3-hexulose-6-phosphate synthase.
based on mapping to UniProt Q9LBW4
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde.
-!- Specific for formaldehyde and D-ribulose 5-phosphate as substrates. -!- Ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. -!- This enzyme, along with EC 5.3.1.27, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds. -!- The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of this enzyme and EC 5.3.1.27.
|
UniProtKB Entries (1)
| Q9LBW4 |
HPS_MYCGS
Mycobacterium gastri
3-hexulose-6-phosphate synthase
|
PDB Structure
| PDB | 3AJX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of 3-hexulose-6-phosphate synthase, a member of the orotidine 5'-monophosphate decarboxylase suprafamily
Proteins
|