CATH Classification
Level | CATH Code | Description |
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4 | Few Secondary Structures |
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4.10 | Irregular |
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4.10.1250 | Aminomethyltransferase fragment |
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4.10.1250.10 | Aminomethyltransferase fragment |
Domain Context
CATH Clusters
Superfamily | Aminomethyltransferase fragment |
Functional Family | Aminomethyltransferase |
Enzyme Information
2.1.2.10 |
Aminomethyltransferase.
based on mapping to UniProt P27248
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
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UniProtKB Entries (1)
P0A6T9 |
GCSH_ECOLI
Escherichia coli K-12
Glycine cleavage system H protein
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PDB Structure
PDB | 3A8I |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
J.Biol.Chem.
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