CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.11040 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.11040 |
Functional Family | tRNA(Met) cytidine acetyltransferase TmcA |
Enzyme Information
2.3.1.193 |
tRNA(Met) cytidine acetyltransferase.
based on mapping to UniProt P76562
(Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA + H(2)O = (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + phosphate + CoA.
-!- The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNA(Met). -!- Escherichia coli TmcA strictly discriminates elongator tRNA(Met) from tRNA(Ile), which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. -!- The enzyme can use GTP in place of ATP for formation of N(4)- acetylcytidine.
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UniProtKB Entries (1)
P76562 |
TMCA_ECOLI
Escherichia coli K-12
TRNA(Met) cytidine acetyltransferase TmcA
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PDB Structure
PDB | 2ZPA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon
Embo J.
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