CATH Domain 2zjtA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1490	Dna Ligase; domain 1
	3.30.1490.440

Domain Context

CATH Clusters

Superfamily	3.30.1490.440
Functional Family

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt P9WG45

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P9WG45

GYRB_MYCTU

Mycobacterium tuberculosis H37Rv

DNA gyrase subunit B

PDB Structure

PDB	2ZJT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation Fu, G.S., Wu, J.J., Liu, W., Zhu, D.Y., Hu, Y.L., Deng, J., Zhang, X.E., Bi, L.J., Wang, D.C. Nucleic Acids Res.