CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.1390 | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 |
Domain Context
CATH Clusters
| Superfamily | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 |
| Functional Family | Leucine-rich repeat serine/threonine-protein kinase 2 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q5S007
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
| Q5S007 |
LRRK2_HUMAN
Homo sapiens
Leucine-rich repeat serine/threonine-protein kinase 2
|
PDB Structure
| PDB | 2ZEJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Proc.Natl.Acad.Sci.Usa
|
