CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.70 | Alpha-Beta Plaits | |
3.30.70.240 |
Domain Context
CATH Clusters
Superfamily | 3.30.70.240 |
Functional Family | Translation factor GUF1, mitochondrial |
Enzyme Information
3.6.5.n1 |
Elongation factor 4.
based on mapping to UniProt O67618
GTP + H(2)O = GDP + phosphate.
-!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner.
|
UniProtKB Entries (1)
O67618 |
LEPA_AQUAE
Aquifex aeolicus VF5
Elongation factor 4
|
PDB Structure
PDB | 2YWH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structures of GTP-binding protein LepA from Aquifex aeolicus.
To be Published
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