CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.240
Functional Family Translation factor GUF1, mitochondrial

Enzyme Information

3.6.5.n1
Elongation factor 4.
based on mapping to UniProt O67618
GTP + H(2)O = GDP + phosphate.
-!- The enzyme is required for accurate and efficient protein synthesis under certain stress conditions. -!- May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. -!- Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. -!- Binds to ribosomes in a GTP-dependent manner.

UniProtKB Entries (1)

O67618
LEPA_AQUAE
Aquifex aeolicus VF5
Elongation factor 4

PDB Structure

PDB 2YWH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of GTP-binding protein LepA from Aquifex aeolicus.
Kawazoe, M., Takemoto, C., Kaminishi, T., Nishino, A., Nakayama-Ushikoshi, R., Hanawa-Suetsugu, K., Terada, T., Shirouzu, M., Yokoyama, S.
To be Published