CATH Classification

Domain Context

CATH Clusters

Superfamily Calponin-like domain
Functional Family Neuron navigator 2

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q8IVL1
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q8IVL1
NAV2_HUMAN
Homo sapiens
Neuron navigator 2

PDB Structure

PDB 2YRN
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the CH domain from Human Neuron navigator 2
Tomizawa, T., Tochio, N., Koshiba, S., Inoue, M., Nakamura, Y., Furukawa, Y., Kigawa, T., Yokoyama, S.
To be Published