CATH Domain 2yi8A05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1270	Substrate Binding Domain Of Dnak; Chain:A; Domain 2
	1.20.1270.270	VP1, C-terminal extension domain

Domain Context

CATH Clusters

Superfamily	VP1, C-terminal extension domain
Functional Family

Enzyme Information

2.7.7.48

RNA-directed RNA polymerase.

based on mapping to UniProt P22173

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P22173

RDRP_IPNVJ

Infectious pancreatic necrosis virus - Jasper

RNA-directed RNA polymerase

PDB Structure

PDB	2YI8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The N-Terminus of the RNA Polymerase from Infectious Pancreatic Necrosis Virus is the Determinant of Genome Attachment. Graham, S.C., Sarin, L.P., Bahar, M.W., Myers, R.A., Stuart, D.I., Bamford, D.H., Grimes, J.M. Plos Pathog.