CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14757
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757
CHK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk1

PDB Structure

PDB 2YEX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors.
Oza, V., Ashwell, S., Brassil, P., Breed, J., Ezhuthachan, J., Deng, C., Grondine, M., Horn, C., Liu, D., Lyne, P., Newcombe, N., Pass, M., Read, J., Su, M., Toader, D., Yu, D., Yu, Y., Zabludoff, S.
Bioorg.Med.Chem.Lett.
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