CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Enzyme Information

2.7.7.60
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt P69834
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P69834
ISPD_ARATH
Arabidopsis thaliana
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic

PDB Structure

PDB 2YC5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitors of the Herbicidal Target Ispd: Allosteric Site Binding.
Witschel, M.C., Hoeffken, H.W., Seet, M., Parra, L., Mietzner, T., Thater, F., Niggeweg, R., Rohl, F., Illarionov, B., Rohdich, F., Kaiser, J., Fischer, M., Bacher, A., Diederich, F.
Angew.Chem.Int.Ed.Engl.