CATH Domain 2xxnA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.210	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
	2.60.210.10	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A

Domain Context

CATH Clusters

Superfamily	Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family	Ubiquitin carboxyl-terminal hydrolase 7

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q93009

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (2)

Q2HR73	VIRF4_HHV8P Human herpesvirus 8 strain GK18 Viral IRF4-like protein
Q93009	UBP7_HUMAN Homo sapiens Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

PDB	2XXN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bilateral Inhibition of Hausp Deubiquitinase by a Viral Interferon Regulatory Factor Protein Lee, H.R., Choi, W.C., Lee, S., Hwang, J., Hwang, E., Guchhait, K., Haas, J., Toth, Z., Jeon, Y.H., Oh, T.K., Kim, M.H., Jung, J.U. Nat.Struct.Mol.Biol.