CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.60 | Wheat Germ Agglutinin (Isolectin 2); domain 1 |
|
3.30.60.30 |
Domain Context
CATH Clusters
| Superfamily | 3.30.60.30 |
| Functional Family | Complement factor I |
Enzyme Information
| 3.4.21.45 |
Complement factor I.
based on mapping to UniProt P05156
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.
-!- Cleavage of complement subcomponent C3b requires its binding to cofactor H or complement receptor CR1; cleavage of iC3b requires complement receptor CR1; cleavage of C4b requires C4b-binding protein. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P05156 |
CFAI_HUMAN
Homo sapiens
Complement factor I
|
PDB Structure
| PDB | 2XRC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
Proc.Natl.Acad.Sci.USA
|
