CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.630 | Cytochrome p450 | |
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450 |
Functional Family | Erythromycin C-12 hydroxylase |
Enzyme Information
1.14.13.154 |
Erythromycin 12 hydroxylase.
based on mapping to UniProt P48635
Erythromycin D + NADPH + O(2) = erythromycin C + NADP(+) + H(2)O.
-!- The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. -!- It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B.
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UniProtKB Entries (1)
P48635 |
ERYK_SACEN
Saccharopolyspora erythraea NRRL 2338
Erythromycin C-12 hydroxylase
|
PDB Structure
PDB | 2XFH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Biochemistry
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