CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Erythromycin C-12 hydroxylase

Enzyme Information

1.14.13.154
Erythromycin 12 hydroxylase.
based on mapping to UniProt P48635
Erythromycin D + NADPH + O(2) = erythromycin C + NADP(+) + H(2)O.
-!- The enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis. -!- It shows 1200-1900-fold preference for erythromycin D over the alternative substrate erythromycin B.

UniProtKB Entries (1)

P48635
ERYK_SACEN
Saccharopolyspora erythraea NRRL 2338
Erythromycin C-12 hydroxylase

PDB Structure

PDB 2XFH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Montemiglio, L.C., Gianni, S., Vallone, B., Savino, C.
Biochemistry