CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2000 | Glycogen Phosphorylase B; |
Domain Context
CATH Clusters
| Superfamily | Glycogen Phosphorylase B; |
| Functional Family | 3-deoxy-D-manno-octulosonic acid transferase |
Enzyme Information
| 2.4.99.12 |
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase.
based on mapping to UniProt O66663
Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.
-!- The bifunctional enzyme from Escherichia coli transfers two 3-deoxy- D-manno-octulosonate residues to lipid IV(A) (cf. EC 2.4.99.13). -!- The monofunctional enzymes from Aquifex aeolicus and Haemophilus influenzae catalyze the transfer of a single 3-deoxy-D-manno- octulosonate residue from CMP-3-deoxy-D-manno-octulosonate to lipid IV(A). -!- The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno- octulosonate residues and generate genus-specific epitopes.
|
UniProtKB Entries (1)
| O66663 |
KDTA_AQUAE
Aquifex aeolicus VF5
3-deoxy-D-manno-octulosonic acid transferase
|
PDB Structure
| PDB | 2XCU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA
|
